WebFinally, clofarabine triphosphate directly induces programmed cell death by causing the release of numerous apoptotic compounds . The pharmacologic effects and activation of clofarabine are predominantly dependent on dCK phosphorylation. dCK is a key enzyme in the deoxyribonucleoside salvage pathway. It phosphorylates free nucleosides such as ... WebMar 24, 2016 · Clofarabine is an FDA approved RNR inhibitor (RNRI) used in the treatment of acute lymphoblastic leukemia. As a purine nucleoside analog (Fig. 1 a), clofarabine is transported into cells by nucleoside transporters and is phosphorylated by host enzymes to the active forms of the drug, clofarabine di- and triphosphate [ 18 ].
CLOLAR® (clofarabine) injection, for intravenous use …
WebDec 24, 2003 · The triphosphate of fludarabine primarily inhibits DNA polymerases, whereas cladribine triphosphate particularly inhibits ribonucleotide reductase. Clofarabine triphosphate has the mechanistically favorable properties of both agents with regard to inhibition of DNA polymerases and ribonucleotide reductase (14, 15, 16, 17). WebOct 3, 2024 · Clofarabine increases the risk of infection, including severe and fatal sepsis, and opportunistic infections. At baseline, 48% of the pediatric patients had one or more concurrent infections. A total of 83% of patients experienced at least one infection after … Usual Adult Dose for Acute Lymphoblastic Leukemia. 18 to less than 22 years: 5… Serious side effects of Clofarabine. Along with its needed effects, clofarabine ma… buildbase walthamstow
Clofarabine Nature Reviews Drug Discovery
WebAug 1, 2014 · Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for quantifying clofarabine triphosphate concentrations in human peripheral blood mononuclear cells … WebOct 1, 2006 · Secondly, clofarabine triphosphate is a potent inhibitor of ribonucleotide reductase (IC 50 = 65 nM), presumably by binding to the allosteric site on the regulatory … WebStructural formula of Clofarabine-5'-triphosphate For general laboratory use. Shipping: shipped on gel packs Storage Conditions: store at -20 °C Short term exposure (up to 1 … buildbase warrington