Egr1 and fibrosis
WebIGFBP2/integrin β1/FAK/ERK/EGR1: Promote proliferation : ADAM17/Notch1/integrin β1: Promote cell migration and invasion : ... The dormant HSC is an important component of the HCC-TME and a key regulator of liver fibrosis and cirrhosis, which contributes to the tumorigenicity and invasiveness of HCC. Recently, it was found that integrins are ... WebThe respiratory system is a well-organized multicellular organ, and disruption of cellular homeostasis or abnormal tissue repair caused by genetic deficiency and exposure to risk factors lead to life-threatening pulmonary disease including idiopathic pulmonary fibrosis (IPF). Although there is no clear etiology as the name reflected, its pathological progress …
Egr1 and fibrosis
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EGR1 has been reported to inhibit tumor invasion and metastasis in many tumor types. TGF-β1 can downregulate EGR1-induced NSCLC cell EMT, and high expression of EGR1 significantly reduces EMT (64). The mechanism may be related to the regulation of SNAIL, SLUG, and E-cadherin expression by EGR1. In … See more Early growth response factor 1 (EGR1) is a member of the EGR family and is also known as EGR-1, NEFI-A, Zif268, Krox-24, and TIS85. The EGR1 gene is located in human chromosomal region 5q23-31, and the protein is an … See more High expression of EGR1 has been observed in various tumors, in which EGR1 can play an oncogenic role, e.g., glioma, lung cancer, … See more Epithelial–mesenchymal transition (EMT) means a morphological change of epithelial cells to mesenchymal cells, which is an important mechanism of tumor cell invasion and … See more Various authors have shown that high EGR1 expression may increase the proliferation of specific types of tumor cells by affecting the cell cycle. For example, the high expression of EGR1 in prostate cancer is a potential … See more WebEGR1 is part of a family of immediate early genes that play a critical role in cellular growth, development and differentiation (1). Both HIF and EGR1 are induced by hypoxia, ... such as ischemia and fibrosis, there has been intense interest in understanding the pathway by which hypoxia alters patterns of gene expression. One of the most
WebJun 9, 2015 · The nuclear transcription factor Egr1 is associated with renal fibrosis [3,4]. In addition, Egr1 is associated with diabetic nephropathy [9,10,11]. The present study … WebApr 11, 2024 · For this purpose we used the three genes: Tgfb2, Egr1 and Ccna2. Tgfb2 is a gene from cluster “Fibrosis” (Supplementary Table1). This gene is a marker of fetal gene program and cardiomyocyte remodeling [99,100 refs from the text]; Egr1 belongs to the cluster “Detoxification” (Supplementary Table2). This gene is a marker of ...
WebMar 11, 2016 · To link EGR1 to DGKA induction after radiation, we tested the effect of siRNA-mediated EGR1 knockdown on DGKA mRNA expression and DAG kinase … WebNov 5, 2024 · As a transcription factor, EGR1 binds to target promoter sequences. A previous study showed for the first time that FGF21 possesses anti-arrhythmic properties owing to its efficacy in protecting Nav1.5 and Kir2.1 channels from ischaemic injury by targeting miR-143/EGR1 signalling (Li et al., 2024).
WebJun 1, 2024 · TITLE: The epigenetic role of EGR1 during postnatal brain development and in neuronal activity Project Summary/Abstract Early growth response gene-1 (Egr1) is a critical transcription factor involved...
WebEGR1, also known as KROX24, NGFIA, and ZIF268, is an immediate early gene containing a DNA-binding domain composed of three zinc-finger motifs.157,158 EGR1 is expressed … glitched display names robloxWebNov 1, 2007 · Following upregulation by injurious stimuli, EGR1 may intensify lung injury through thrombosis, edema formation, fibrosis, and apoptosis. EGR1 has been shown … body vases isabella haleyWebApr 11, 2002 · Tubulointerstitial inflammations and fibrosis are common features in a variety of progressive renal diseases. It may determine the degree of impairment of renal … glitched discord usernameWebMar 9, 2016 · Our study highlights the integrative role of Egr-1 in renal inflammation and fibrosis. Thus, Egr-1 may serve as a therapeutic target for human kidney diseases. Key messages Renal failure activates Egr-1 in human and mouse tubular cells. Egr-1 deficiency attenuates NF-κB and TGFβ-mediated renal inflammation/fibrosis. glitched dokisWebNov 10, 2024 · Egr‐1 stimulates angiogenesis in a range of settings including wound healing, corneal neovascularization, and tumor angiogenesis. 49 Adenoviral delivery … body veins and arteriesWebMar 9, 2016 · Our study highlights the integrative role of Egr-1 in renal inflammation and fibrosis. Thus, Egr-1 may serve as a therapeutic target for human kidney diseases. Key … body vascular systemWebFeb 28, 2024 · As EGR1 is systematically mentioned as being involved in fibrosis progession in organ fibrosis animal models, Egr1 is seen as a putative target to fight fibrosis. A recent antifibrotic chemical component … glitched domortuus