Gephyronic acid
WebIn this work we establish the activity and substrate preference for six MTs from the gephyronic acid polyketide synthase and demonstrate their ability to methylate both N-acetylcysteamine- and acyl carrier protein-linked β … WebMyxococcales. Les Myxococcales, ou Myxobacteria ou Myxobactéries, sont un ordre de bactéries que l'on trouve en majorité dans le sol et qui se nourrissent de composés organiques insolubles. Elles font partie de la classe des Deltaproteobacteria, un grand taxon de bactéries à Gram négatif. La plupart des myxobactéries connues se ...
Gephyronic acid
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WebInvestigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic … WebSynthesis and Biological Evaluation of Gephyronic Acid Derivatives: Initial Steps towards the Identification of the Biological Target of Polyketide Inhibitors of Eukaryotic Protein Synthesis. European Journal of Organic Chemistry 2011, 2011 (36) , 7294-7307.
WebDec 12, 2024 · Isotopic labeling of the gephyronic acid producer Cystobacter violaceus with 13 C-methyl-L-methionine demonstrated that the isobutyryl starter group is derived from S-adenosylmethionine (SAM) and not from valine, likely via GphF MT1 18. The MT1-containing loading modules also include a mysterious ~150-residue N-terminal “adaptor … WebTheoretical study on substrate recognition and catalytic mechanisms of gephyronic acid dehydratase DH1† Lei Liu , ‡ a Qian Yu , ‡ a Haoqing Zhang , a Wentao Tao , a Rufan Wang , a Linquan Bai , a Yi-Lei Zhao a …
WebElucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM … WebGephyronic acid also showed a cytostatic effect in mam-malian cell cultures (Table 2). The IC50 values varied from 10 to 60ng/ml. The hemiacetal was also tested against different fungi and the mouse cell line L929, but there was no significant difference between both forms of gephyronic acid concerning their biological activities in these assays.
WebFeb 7, 2007 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid. Angewandte Chemie International Edition 2011, 50 (4) , 938-941. DOI: 10.1002/anie.201005530.
Gephyronic acid is a polyketide that exists as an equilibrating mixture of structural isomers. In nature, gephyronic acid is produced by slow growing myxobacterium: Archangium gephyra strain Ar3895 and Cystobacter violaceus strain Cb vi76. It is the first antibiotic in myxobacteria that was reported … See more Preliminary studies demonstrated that gephyronic acid inhibited growth of yeast and molds as well as elicited a cytostatic effect through the inhibition of eukaryotic protein synthesis in mammalian cell cultures. Feeding … See more Sequencing of the PKS gene cluster in C. violaceus was conducted and confirmed to reveal five type I polyketide synthases and post-PKS tailoring enzymes with O-methyltransferase and cytochrome P450 monooxygenase. The overall structure correlates well with … See more alexandria virginia business licenseWebJul 31, 2024 · Gephyronic acid seems to have a different mode of action than the … alexandria va top golfWebCoupled to the development of a total synthesis of gephyronic acid, a series of diastereomeric analogues and their precursors have been prepared by employing complementary aldol strategies for the ... alexandrian manifesto - page 4WebDec 29, 2010 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of … alexandria virginia standoffWebSep 27, 2016 · Greg J. Dodge, Danialle Ronnow, Richard E. Taylor, Janet L. Smith, Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase, ACS Chemical Biology, 10.1021/acschembio.8b00645, 13, 9, ... A Vibrational CD Study on Carboxylic Acid Binding, Chemistry – A European Journal, 10.1002/chem.202404230, … alexandria zionWebJul 31, 2024 · Gephyronic acid seems to have a different mode of action than the … alexandria virginia to nycWebFeb 8, 2010 · Richard Taylor from the Department of Chemistry and Biochemistry – to identify the key steps in the biosynthesis of gephyronic acid, a natural product isolated from a bacteria that has been shown to inhibit growth of yeast and mold, as well as a range of mammalian cell types. Identification of the gene cluster responsible for biosynthesis ... alexandria virginia to dc