WebbBackground. Becker’s type Myotonia Congenita (BTMC) (MIM 255700) 1 is an autosomal recessive nondystrophic skeletal muscle disorder caused by mutations in the CLCN1 gene. 1 Clinically, the disease is characterized by muscle stiffness and the inability to relax after voluntary contraction. 2 The CLCN1 gene is located on chromosome 7q34 NC ... WebbIn a formal, single-dose interaction study (n = 6 males) the clearance of mexiletine was decreased by 38% following the coadministration of fluvoxamine, an inhibitor of CYP1A2. In another formal study (n = 8 extensive and n = 7 poor metabolizers of CYP2D6), coadministration of propafenone did not alter the kinetics of mexiletine in the poor …
Amiodarone/mexiletine/sotalol SpringerLink
WebbOther medications can affect the removal of mexiletine from your body, which may affect how mexiletine works. Examples include cimetidine, fluvoxamine, propafenone, rifampin, anti-seizure drugs (such as phenytoin, phenobarbital), among others. This document does not contain all possible interactions. Webb28 dec. 2024 · Mexiletine is a class I b antiarrhythmic drug and is also used clinically to reduce or prevent myotonia. In addition, mexiletine has neuroprotective effects in models of brain ischemia. We compared state-dependent affinities of mexiletine for Na v 1.2, Na v 1.4 and Na v 1.5, and examined the effects of mutations of ksm96 accessories
Mexiletine - an overview ScienceDirect Topics
WebbMexiletine Propylamines Anti-Arrhythmia Agents Disopyramide Nisin Caffeine. Analytical, Diagnostic and Therapeutic Techniques and Equipment 3. Protective Devices Reference Standards Drug Overdose. Psychiatry and Psychology 2. Judgment Alcohol Drinking. Phenomena and Processes 3. Sound ... Webb1 feb. 2024 · Mexiletine is widely used as an antiarrhythmic drug for patients with LQT3 syndrome and ventricular tachycardia. Patient-specific responses to mexiletine have been observed in clinical studies. However, the underlying mechanism is not well defined due to the lack of understanding of mexiletine’s molecular interactions with the Na V 1.5 Webb7 DRUG INTERACTIONS . 7.1 Mexiletine . 8 USE IN SPECIFIC POPULATIONS . 8.1 Pregnancy 8.3. Pediatric Use 8.5 Geriatric Use . 10 OVERDOSAGE 11 DESCRIPTION 12 CLINICAL PHARMACOLOGY . 12.1 . Mechanism of Action 12.2 . Pharmacodynamics 12.3 . Pharmacokinetics . 13 NONCLINICAL TOXICOLOGY . 13.1 Carcinogenesis, … ksm95cu attachments