2024 Paprotrain discover

Paprotrain discover

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August undefined, 2024

WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition … WebPaprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K = 3.4 μ M). Inhibits the basal ATPase activity of MKLP-2 (IC 50 = 1.35 μ M). …

Paprotrain Kinesin TargetMol

WebApplication: Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2) CAS Number: 57046-73-8 Purity: ≥98% Molecular Weight: 245.28 Molecular Formula: C 16 H 11 N 3 For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. * Refer to Certificate of Analysis for lot specific data (including water content). Nov 28, 2015 · burning cliffs raven

Kinesin Inhibition Kinesin Inhibitor Review & List - selleckchem

WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. Paprotrain has been screened on … WebCatalog No. Product Name Information Product Use Citations Product Validations; E0779 New: Paprotrain: Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.: E1180 New: Sovilnesib WebApr 13, 2024 · Paprotrain (PAssenger PROteins TRAnsport INhibitor), is a cell permeable, reversible, ATP-uncompetitive inhibitor of the ATPase region of KIF20A. This inhibitor is … burning city fantasy art

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Paprotrain (CAS 57046-73-8): R&D Systems

WebBELLA Italia Ristorante. 13848 Tilden Rd #192, Winter Garden, FL 34787. We were meeting old friends and wanted to share a long lunch reminiscing. The staff was wonderful in … WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM. burning classicsWebPaprotrain is a reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (K i = 3.4 μ M). Inhibits the basal ATPase activity of MKLP-2 (IC 50 = 1.35 μ M). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable. burning cliffs collectibles

"WebThe MKLP-2 Inhibitor, Paprotrain controls the biological activity of MKLP-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. MKLP-2 Inhibitor, Paprotrain - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References Data Sheet " - Paprotrain discover

Paprotrain discover

New MKLP-2 Inhibitors in the Paprotrain Series: Design …

WebNov 29, 2016 · Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors Further investigation of Paprotrain: Towards the … WebDec 1, 2010 · The application of chemical proteomics to new target discovery can lead to a rapid understanding of disease mechanism and new therapeutic methods. Successful …

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WebPaprotrain es un inhibidor permeable a las células de la quinesina MKLP-2, inhibe la actividad ATPasa de MKLP-2 con una IC50 de 1,35 μM y una Ki de 3,36 μM y muestra una actividad de inhibiciÓn moderada sobre DYRK1A con una IC50 de 5,5 μM. WebFeb 15, 2016 · Paprotrain 1. Introduction Mitosis is a highly regulated process that separates the replicated sister chromatids equally into the daughter cells. One class of …

WebPaprotrain is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, paprotrain should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Paprotrain has a solubility of approximately 0.1 mg/ml in a 1:6 solution of DMSO:PBS (pH 7.2) using this method. We do not

WebPaprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition …

WebPinspiration South Orlando Craft Studio - Parties, Paint & Sip, Events. 14416 Shoreside Way Unit 100, Winter Garden, FL, 34787. (407) 500-7467. burning city in paWebBuy Paprotrain (CAS No. 57046-73-8) from Smolecule. Molecular Formula: C16H11N3. Molecular Weight: 245.28 g/mol. Selective cell-permeable MKLP-2 inhibitor. hamburg mn fish fryWebBiological description. Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC 50 values are 1.35 and 0.83 µM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I. burning city in pennsylvaniaWebDec 1, 2015 · In this regard, Paprotrain has been described as a potent inhibitor of KIF20A in HL60 (human myeloid leukemia cell line), leading to multinuclearity of these cells and … hamburg mn countyWebJan 21, 2024 · The park entrance station is a booth that is located literally in the middle of the road. So once you get on Park Road 22, just keep going until you reach the end and … hamburg models camerasWebMay 7, 2024 · The suppression of endogenous KIF20A expression using small interfering ribonucleic acids or via treatment with paprotrain, a selective inhibitor of KIF20A, significantly inhibited breast cancer cell growth through cell cycle arrest at the G2/M phase and subsequent mitotic cell death. burning clocks brightonWebFeb 15, 2016 · We have previously identified compound 1 (paprotrain) as the first selective inhibitor of MKLP-2. Herein we describe the synthesis and biological evaluation of new … hamburg mopo news