Phenotypically modulated
WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female … WebApr 25, 2024 · The effects of smooth muscle cell apoptosis and necrosis accompanied by extracellular matrix degradation is believed to be the major processes leading to the weakening of the aortic wall and could be one of the major causes of AAA rupture; however, the mechanisms that regulate AAA rupture remain unknown (Henderson et al. 1999; …
Phenotypically modulated
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WebNov 11, 2024 · In-depth single-cell RNA sequencing demonstrates that SMC-Has3 deletion driven expansion of phenotypically modulated SMC drives increases in acute-phase response gene expression. Blocking the important HA binding receptor, cluster of differentiation-44 (CD44), recapitulates the enhanced acute-phase response and … WebFeb 8, 2024 · Differentially expression analysis revealed that, compared to Rgs5 low SMCs, Rgs5 high SMCs expressed significantly higher levels of molecular signatures for phenotypically modulated SMCs as ...
WebSep 15, 2024 · these SMC progenies have been previously lumped together as phenotypically modulated SMC, advances in single cell RNA profiling has demonstrated the presence of subsets of these cells with distinct transcriptomes and cell fates. For example, medial SMC have been shown to give WebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched and included several publicly available single-cell datasets from the GEO database, resulting in an inclusion of more than 80,000 cells.
WebApr 1, 2009 · The phenotypic modulation of SMCs plays an important role in normal vascular development as well as the progression of vascular diseases such as atherosclerosis and … WebNov 8, 2024 · The root system architecture (RSA) of plants is highly dependent on the surrounding nutrient environment. The uptake of essential nutrients triggers various signaling cascades and fluctuations in plant hormones to elicit physical changes in RSA. These pathways may involve signaling components known as small signaling peptides …
WebVICs express number of VSMC-specific proteins and display features of phenotypically modulated VSMCs with increased migratory abilities. VICs, therefore represent resident …
WebSingle cell RNA sequencing (scRNA-Seq) identified phenotypically modulated SMCs (mSMCs) characterized by upregulation of macrophage, fibroblast, and chrondrocyte markers that appear with atherosclerotic plaque formation in Apoe-/- mice aortas. This transition is dependent on Kruppel-like factor 4 (Klf4). ia3 englishWebThis increase in the number of phenotypically modulated perivascular cells was specific to pre-metastatic lung tissue, in that a similar expansion of perivascular cells was not seen in other... ia3 chemistryWebApr 15, 2014 · Studies within this dissertation are focused on identifying phenotypically modulated SMCs within atherosclerotic lesions using a newly developed conditional SMC specific lineage tracing mouse model, and a novel method that allows for the visualization of histone modifications of single genomic loci with single-cell resolution in formaldehyde ... molokai high school staffWebJun 26, 2008 · Animal Model KLF5 is a transcription factor for Smemb/nonmuscle myosin heavy chain B, which is a molecular marker of phenotypically modulated smooth muscle cells. Normally, KLF5 is abundantly expressed in developing blood vessels, but is downregulated in adult vessels. molokai helicopter tourWebJun 1, 2012 · Phenotypically modulated SMCs are characterized by a decreased expression of SMC-specific proteins and show a high degree of proliferation and the ability to … ia3 general math exam 2022 answersWebThe phenotype of the intimal SMCs gradually returned to the differentiated-type from the deep intima after 2 months, but a small number of the intimal SMCs remained in the dedifferentiated phenotype even at 6 months after the operation. molokai high school sports physical formWebAug 1, 2024 · In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of... ia3 food and nutrition