Web12. jan 2024 · To screen Gfi1aa downstream targets, we performed RNA-seq and ChIP-seq analysis and found two endothelial transcription factors, etv2 and sox7, to be repressed by Gfi1aa. Genetic analysis demonstrated Gfi1aa to promote hemangioblast differentiation into primitive erythrocytes by inhibiting both etv2 and sox7 in an Lsd1-dependent manner. WebSlug (SNAI2) and SRY-related HMG box 7 (SOX7) transcriptional repressors were identified and shown to bind specifically to the HBVCP by electrophoretic mobility shift assay. The resultant inhibitory effect on HBVCP transcription was validated using luciferase reporter and assays for pgRNA, HBcAg and cccDNA accumulation in cells with HBV ...
Frontiers Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation …
Web5. mar 2024 · Our findings establish that Sox7 promotes tumor growth via vessel abnormalization, and its level determines the therapeutic outcome of VEGFR2 inhibition in … Web15. feb 2024 · Our findings suggest that Sox7 plays an important role in mediating HLA I antibody-dependent endothelial cell activation and acute kidney allograft rejection via the … cpt code for breast i and d
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Web29. nov 2013 · SOX7 binding to the VE-cadherin promoter led to its activation in a reporter assay in HEK293 cells, and the integrity of the SOX7 binding site proximal to the transcription start site is necessary for complete promoter activation in bEnd.3 endothelial cells (Costa et al., 2012). WebVascular Endothelial Cell Growth Factor B (VEGF-B) Vascular Endothelial Cell Growth Factor A (VEGF-A) Vascular Endothelial cell Growth Factor (VEGF) Vascular Endothelial Cadherin (VE-Cadherin) VAPB. Vanillylmandelic Acid (VMA) VANGL1. VAMP8. VAMP4. VAMP2. VAMP1. VAMP-1/2/3. VACM-1. V5 Epitope Tag. Web21. apr 2013 · Costa, G. et al. SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. Development 139 … cpt code for breast spot compression