WebMay 13, 2024 · STAT6 serves important roles in signal transduction throughout the cytoplasm and is a transcription factor in the nucleus. Cytokines and growth factors bind to their cognate receptors and activate the JAK family. Once activated, JAKs phosphorylate docking sites in the SH2 domain of STAT molecules. Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT … See more In the human genome, STAT6 protein is encoded by the STAT6 gene, located on the chromosome 12q13.3-q14.1. The gene encompasses over 19 kb and consists of 23 exons. STAT6 shares structural similarity with the … See more STAT6-mediated signaling pathway is required for the development of T-helper type 2 (Th2) cells and Th2 immune response. Expression of Th2 cytokines, including IL-4, IL-13, and IL-5, was reduced in STAT6 - / - mice. STAT 6 protein is crucial in IL4 … See more • Gene fusion • Amplification See more • STAT6+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more STAT6 has been shown to interact with: • CREB-binding protein, • EP300, • IRF4, • NFKB1, See more • Interleukin 4 See more • Jiang H, Harris MB, Rothman P (June 2000). "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1063–70. See more
The alternative macrophage relay: STAT6 passes the baton to EGR2
WebNov 26, 2024 · The JAK/STAT signaling pathway was first discovered when studying how IFNs lead to the activation of a transcription factor. 11 In 1990, the transcriptional activator interferon-stimulated gene... WebMay 25, 2000 · STATs (signal transducers and activators of transcription) are transcription factors that provide a direct link between the cytokine receptors and cytokine induced … process and controls
Modulation of M2 macrophage polarization by the crosstalk between Stat6 …
WebApr 12, 2024 · Introduction. The STAT (signal transducer and activator of transcription) proteins are an evolutionarily conserved family of seven transcription factors in mammals, namely STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6 [1].These proteins are the substrate of both receptor and non-receptor tyrosine kinases such as the Janus … WebThe transcription factor STAT6 (Signal Transducer and Activator of Transcription 6) is a key regulator of Th2 (T-helper 2) mediated allergic inflammation via the IL-4 (interleukin-4) … WebNov 26, 2024 · The transcription factor STAT3 is activated by the IL-6 family members (IL-6, IL-11, IL-31, LIF, CNTF, CT-1, OSM, etc.), IL-10 family members (IL-10, IL-19, IL-20, IL-22, IL … process and capacity analysis